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KMID : 0356420010190010049
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Journal of Korean Andrology
2001 Volume.19 No. 1 p.49 ~ p.56
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Effect of Bisphenol A on the Erectile Tissues of the Rabbit
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Moon Du-Geon
Park Hong-Seok
Cho Hyun-Yee
Yeo Jeong-Kyun
Kim Je-Jong
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Abstract
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Previously, we demonstrated the changes of erectile tissues by intraperitoneal administration of BPA with toxic dose (cumulative dose of 900 ㎎) in the rabbit. We performed this study to investigate the changes of erectile tissues by
intracavernosal administration of BPA with low dose. New Zealand white rabbits were treated intracavernosally with 1 ㎎, 1 ug, 1ng, and 1 pg of BPA. Four weeks after administration of BPA, the contractions and relaxation of cavernosal tissue strips were significantly suppressed in the BPA-treated animals in a dose dependent fashion compared with the control animals. Histologically, thickening of tunica albuginea by increased collagen fibers, subtunical deposition of fat, and decreased sinusoidal space by severe cavernosal smooth muscle hyperplasia with fibrosis were observed in the BPA treated animals. These results suggest that xenoestrogen BPA may affect the erectile function through evident histological changes of the penis in low dose.
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KEYWORD
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Endocrine disruptor, Bisphenol A, Erection, Penis,
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